Orthogonally Protected Diaminocyclopentenones as Synthons: Total Synthesis of (±)-Agelastatin A.

Natural products containing aminocyclopentanes are common secondary metabolites, often biologically active. This work aims at the preparation of a useful synthon for total synthesis containing orthogonally protected amines. To this end, furfural and two amines were employed to form mixed -4,5-diaminocyclopentenones promoted by Cu(OTf).

Palliative care interventions for people with multiple sclerosis.

Background: People with multiple sclerosis (MS) have complex symptoms and different types of needs. These demands include how to manage the burden of physical disability as well as how to organise daily life, restructure social roles in the family and at work, preserve personal identity and community roles, keep self-sufficiency in personal care, and how to be part of an integrated care network. Palliative care teams are trained to keep open full and competent lines of communication about symptoms and disease progression, advanced care planning, and end-of-life issues and wishes.

Socialization of nurses in the Family Health Strategy: contributions to professional identity.

Objective: To verify how socialization of nurses in the Family Health Strategy (FHS) influences their professional identity.

Method: Exploratory, descriptive research, whose theoretical-methodological framework was dialectical hermeneutics, anchored in the premises of the Sociology of Professions. Data were collected through semi-structured interviews with 27 nurses from the FHS of the city of São Paulo.

Taxonomic distribution, structure/function relationship and metabolic context of the two families of sulfide dehydrogenases: SQR and FCSD.

Hydrogen sulfide (HS) is a versatile molecule with different functions in living organisms: it can work as a metabolite of sulfur and energetic metabolism or as a signaling molecule in higher Eukaryotes. HS is also highly toxic since it is able to inhibit heme cooper oxygen reductases, preventing oxidative phosphorylation. Due to the fact that it can both inhibit and feed the respiratory chain, the immediate role of HS on energy metabolism crucially relies on its bioavailability, meaning that studying the central players involved in the HS homeostasis is key for understanding sulfide metabolism.

Polysaccharides isolated from Digenea simplex inhibit inflammatory and nociceptive responses.

Polysaccharides (PLS) have notably diverse pharmacological properties. In the present study, we investigated the previously unexplored anti-inflammatory and antinociceptive activities of the PLS fraction isolated from the marine red alga Digenea simplex. We found that the PLS fraction reduced carrageenan-induced edema in a dose-dependent manner, and inhibited inflammation induced by dextran, histamine, serotonin, and bradykinin.

The contribution of the teaching-service integration to the implementation of the health surveillance model: educators' perspective.

This descriptive-qualitative research aimed to describe how educators perceive the integration between teaching and health services in São Paulo, SP, Brazil and the contribution of this partnership to the implementation of the Health Surveillance (HS) model. Data were collected through semi-structured interviews and analyzed according to the Collective Subject Discourse technique. Results revealed that there is integration between teaching and service, mainly at the initiative of the academy.