Cotard's syndrome in a patient with schizophrenia-spectrum disorder.

Cotard's delusion is a delusion where one believes they are dead or deny aspects of their existence. Cotard's syndrome includes expansive variation in presentations as well as inciting factors. Cotard's syndrome is relatively rare and may include nihilistic delusions that one is missing organs, cannot die or that one does not truly exist.

Delusions of Glass Under Skin: An Unusual Case of Somatic-Type Delusional Disorder Treated with Olanzapine.

Introduction: The management of delusional disorder (DD) remains difficult due to poor patient insight and a lack of definitive treatment guidelines. For the somatic subtype specifically, prior studies have shown successful treatment with the first-generation antipsychotics (FGA) pimozide, but these studies did not specify the nature of the delusions. It has been theorized that pimozide effectiveness is due to its unique ability to relieve itching sensations, which are commonly associated with somatic delusions (e.

Chronic Synthetic Marijuana Use: A Case of First-Onset Seizures as a Withdrawal Symptom.

A 44-year-old male with no known past medical history but a known history of daily synthetic marijuana use presented to the emergency department after two witnessed seizures. The patient was admitted to the neurology service, where he was worked up with an MRI with epilepsy protocol and an EEG. During admission, the patient was admitted to daily synthetic marijuana use.

Alternative Options for Complex, Recurrent Pain States Using Cannabinoids, Psilocybin, and Ketamine: A Narrative Review of Clinical Evidence.

With emerging information about the potential for morbidity and reduced life expectancy with long-term use of opioids, it is logical to evaluate nonopioid analgesic treatments to manage pain states. Combinations of drugs can provide additive and/or synergistic effects that can benefit the management of pain states. In this regard, tetrahydrocannabinol (THC) and cannabidiol (CBD) modulate nociceptive signals and have been studied for chronic pain treatment.

Selective Serotonin Reuptake Inhibitors and Clozapine: Clinically Relevant Interactions and Considerations.

The monoamine hypothesis of depression attributes the symptoms of major depressive disorders to imbalances of serotonin, noradrenaline, and dopamine in the limbic areas of the brain. The preferential targeting of serotonin receptor (SERT) by selective serotonin reuptake inhibitors (SSRIs) has offered an opportunity to reduce the range of these side effects and improve patient adherence to pharmacotherapy. Clozapine remains an effective drug against treatment-resistant schizophrenia, defined as failing treatment with at least two different antipsychotic medications.