GST-4-Dependent Suppression of Neurodegeneration in Models of Parkinson's and Machado-Joseph Disease by Rapeseed Pomace Extract Supplementation.

Genetic mutations and aging-associated oxidative damage underlie the onset and progression of neurodegenerative diseases, like Parkinson's disease (PD) and Machado-Joseph disease (MJD). Natural products derived from plants have been regarded as important sources of novel bioactive compounds to counteract neurodegeneration. Here, we tested the neuroprotective effect of an ethanolic extract of rapeseed pomace (RSP), a rapeseed (canola) oil production by-product, in models of MJD and PD.