Publications by authors named "Juliana Brandstetter Vilar"
Proliferating cell nuclear antigen (PCNA) is a sliding clamp protein that coordinates DNA replication with various DNA maintenance events that are critical for human health. Recently, a hypomorphic homozygous serine to isoleucine (S228I) substitution in PCNA was described to underlie a rare DNA repair disorder known as PCNA-associated DNA repair disorder (PARD). PARD symptoms range from UV sensitivity, neurodegeneration, telangiectasia, and premature aging.
View Article and Find Full Text PDFTherapy of malignant glioma depends on the induction of O-methylguanine by the methylating agent temozolomide (TMZ). However, following TMZ exposure, most glioma cells evade apoptosis and become senescent and are thereby protected against further anticancer therapy. This protection is thought to be dependent on the senescent cell anti-apoptotic pathway (SCAP).
View Article and Find Full Text PDFArticle Synopsis
- Scientists studied a protein called Survivin to see how it affects brain cancer cells when treated with a medicine called temozolomide (TMZ).
- They found that when Survivin was stuck in the nucleus (the cell's control center), the cells couldn't repair damage caused by TMZ, leading to cell aging instead of death.
- In contrast, when Survivin was free to move in the cell, it helped the cancer cells repair themselves and survive better after the treatment.