Publications by authors named "Juliana Assis Martins"
Article Synopsis
- The formamidase (FMD) enzyme is crucial for the survival of Paracoccidioides lutzii by providing a secondary nitrogen source, especially under stressful conditions.
- Research using Galleria mellonella larvae showed that silencing the fmd gene led to reduced fungal burden, disorganized nodules, and impaired immune response.
- The study concludes that formamidase is a significant virulence factor for P. lutzii since its absence increased the larvae's survival rate, highlighting its role in immune stimulation.
Farnesol is a natural essential oil with antimicrobial properties. Complexation of farnesol in chitosan nanoparticles can be useful to improve its bioavailability and potentiate its antifungal capabilities such as inhibition of hyphal and biofilm formation. The aim of this study was to develop and characterize chitosan nanoparticles with farnesol (NF) and evaluate their toxicity and antifungal action on C.
View Article and Find Full Text PDFWound healing in diabetic patients remains a worldwide problem that can cause amputations and even lead to death. This work aimed to produce lecithin-chitosan nanoparticles loaded with melatonin (MEL-NP) incorporated in a topical formulation to be evaluated for healing in the in vivo animal model for diabetes. To produce nanoparticles, an ethanolic solution containing soybean lecithin and melatonin was added dropwise to an aqueous solution of chitosan under sonication.
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