Publications by authors named "Juliana A. U. Anzai"

Background: The multi-day Boston Remote Assessment of Neurocognitive Health (BRANCH) is a remote, web-based assessment designed to capture the earliest cognitive changes in the preclinical stage of Alzheimer's disease (AD). It has been validated in unimpaired older adults, but as individuals progress on the AD continuum, assessments need to remain feasible and valid at different clinical stages. The focus of this study was to assess feasibility and validity of multi-day BRANCH in participants with and without cognitive impairment.

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Article Synopsis
  • The study investigates how the monoclonal antibody lecanemab, used for treating Alzheimer's by targeting amyloid beta, interacts with plasma proteins, particularly focusing on its relatively short half-life due to these interactions.
  • * Researchers employed techniques like ELISA and western blotting to analyze the binding of a lecanemab biosimilar to plasma proteins, identifying fibrinogen as a potential binding partner.
  • * The findings suggest that fibrinogen levels could affect the availability of lecanemab in the bloodstream, highlighting the importance of considering plasma protein binding in the clinical use of therapeutic antibodies for neurodegenerative diseases.
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Subjective cognitive decline (SCD), which precedes Mild Cognitive Impairment and dementia, may be affected by purpose in life (PiL) and loneliness in older adults. We investigated associations among PiL, loneliness, and SCD in US Latino ( = 126), Black ( = 74), Asian ( = 33), and White ( = 637) adults. Higher PiL predicted lower SCD in all groups (p-values < .

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Prior teleneuropsychological research has assessed the reliability between in-person and remote administration of cognitive assessments. Few, if any, studies have examined the test-retest reliability of cognitive assessments conducted in sequential clinic-to-home or home-to-home teleneuropsychological evaluations - a critical issue given the state of clinical practice during the COVID-19 pandemic. This study examined this key psychometric question for several cognitive tests administered over repeated videoconferencing visits 4-6 months apart in a sample of healthy English-speaking adults.

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