The landscape of RNA-chromatin interaction reveals small non-coding RNAs as essential mediators of leukemia maintenance.

RNA constitutes a large fraction of chromatin. Spatial distribution and functional relevance of most of RNA-chromatin interactions remain unknown. We established a landscape analysis of RNA-chromatin interactions in human acute myeloid leukemia (AML).

Germline and somatic drivers in inherited hematologic malignancies.

Inherited hematologic malignancies are linked to a heterogenous group of genes, knowledge of which is rapidly expanding using panel-based next-generation sequencing (NGS) or whole-exome/whole-genome sequencing. Importantly, the penetrance for these syndromes is incomplete, and disease development, progression or transformation has critical clinical implications. With the earlier detection of healthy carriers and sequential monitoring of these patients, clonal hematopoiesis and somatic driver variants become significant factors in determining disease transformation/progression and timing of (preemptive) hematopoietic stem cell transplant in these patients.

Concurrent light chain amyloidosis and proximal tubulopathy: Insights into different aggregation behavior-A case report.

Due to differences in the protein folding mechanisms, it is exceedingly rare for amyloid light chain (AL) amyloidosis and monoclonal gammopathy of renal significance (MGRS) to coexist. We herein report the first case of concurrent AL amyloidosis and a subclass of MGRS, light chain proximal tubulopathy (LCPT). The 53-year-old female was diagnosed with smoldering myeloma immunoglobulin G and AL amyloidosis with deposits in fat and gastrointestinal tissue.

A Novel Apparatus for Simultaneous Laser-Light-Sheet Optical Particle Counting and Video Recording in the Same Measurement Chamber at High Temperature.

A novel apparatus was developed, to investigate the detachment of particle structures consisting of soot and ash from a single fibre or a fibre array in hot gas flow. Key features of the novel apparatus are operation at high temperatures while two different measurement techniques are applied simultaneously in the same measurement chamber to observe particle structure detachment from a loaded fibre array. A heated inlet can heat the air stream at the position of the fibre array up to 470 °C, allowing detachment investigations at temperatures relevant for the operation of, e.