Publications by authors named "Julian Vivek Leander Xavier"
Article Synopsis
- The study examines the effects of different booster vaccines on immune responses in individuals who initially received either the ChAdOx1 nCov-19 or BBV152 vaccines, focusing on participants randomized into four groups for their booster shots.
- Results showed that ChAd boosted individuals exhibited higher memory-B cell frequencies and anti-spike IgG levels compared to those receiving the BBV152 booster, regardless of their primary vaccine.
- The findings also indicated that those in Group 3 (who received ChAd after two doses of BBV152) had a significantly better ability to inhibit the Omicron variant, suggesting the effectiveness of cross-boosting strategies in enhancing immune responses.
Background: Primary SARS-CoV-2 vaccination has been shown to wane with time and provide lower protection from disease with new viral variants, prompting the WHO to recommend the administration of booster doses. We determined the safety and immunogenicity of homologous or heterologous boosters with ChAdOx1 nCoV-19 (COVISHIELD™) or BBV152 (COVAXIN®), the two vaccines used widely for primary immunization in India, in participants who had already received two primary doses of these vaccines.
Methods: Participants primed with two doses each of COVISHIELD™ or COVAXIN® 12-36 weeks previously, were randomised to receive either COVISHIELD™ or COVAXIN® booster in a 1:1 ratio.