Mediators of Corneal Haze Following Implantation of Presbyopic Corneal Inlays.

Purpose: To identify protein mediators of corneal haze following presbyopic corneal inlay surgery.

Methods: Tears were collected from eyes with corneal haze following surgery with a shape-changing corneal inlay. Samples were subjected to quantitative proteomic analysis using iTRAQ and proteins significantly increased or decreased (1.

Epithelium-on photorefractive intrastromal cross-linking (PiXL) for reduction of low myopia.

Purpose: To report the 9-12-month outcomes of a novel procedure for reduction of low myopia through epithelium-on photorefractive intrastromal cross-linking (PiXL) with customized control of topographic distribution of ultraviolet (UV)-fluence.

Method: Myopic patients with normal (non-ectatic) corneas underwent the PiXL procedure for reduction of low myopia. PiXL treatments were delivered through selective application of UVA light based on the refractive error of each patient.

Keratoprosthesis surgery for end-stage corneal blindness in asian eyes.

Purpose: To establish a multidisciplinary surgical program for osteo-odonto-keratoprosthesis (OOKP) surgery in Asia and to evaluate efficacy and preliminary safety of this keratoprosthesis in end-stage corneal and ocular surface disease.

Design: Prospective noncomparative case series.

Participants: Sixteen adults of Asian ethnic origin, bilaterally blind with end-stage corneal blindness from Stevens-Johnson syndrome, or severe chemical or thermal burns.

Infectious keratitis after laser epithelial keratomileusis.

Purpose: To report two cases of infectious keratitis occurring after laser epithelial keratomileusis (LASEK).

Methods: Two patients who underwent LASEK were referred to our center for the management of postoperative infectious keratitis. Infection occurred on postoperative days 2 (case 1) and 5 (case 2).

Compressive C-shaped lamellar keratoplasty: a surgical alternative for the management of severe astigmatism from peripheral corneal degeneration.

Objective: To describe a compressive lamellar surgical technique for treating severe astigmatism in peripheral corneal ectasia.

Design: Retrospective, noncomparative, interventional case series.

Participants: Four eyes of 3 patients with either pellucid or Terrien's marginal corneal degeneration were included in this series.

Pharmacokinetic and toxicity study of an intraocular cyclosporine DDS in the anterior segment of rabbit eyes.

Purpose: To establish the safety and pharmacokinetic efficacy of an Oculex Drug Delivery System (DDS; Oculex Pharmaceuticals, Inc., Sunnyvale, CA) containing cyclosporin A (CsA) in the anterior segment of the rabbit eye.

Methods: The Oculex DDS is an intraocular, sustained-release, drug delivery system comprising a biodegradable lactic acid-glycolic acid copolymer.

Microsporidial keratoconjunctivitis in healthy individuals: a case series.

Purpose: To present a series of 6 cases of microsporidial keratoconjunctivitis in healthy, nonimmunocompromised individuals.

Design: Retrospective, noncomparative case series.

Participants: Six individuals with unilateral keratoconjunctivitis.

Distribution of cyclosporin A in the cornea after topical or oral administration.

The purpose of this study was to determine levels of cyclosporin A (CsA) in ocular tissues and fluids after oral or topical administration of CsA in humans requiring immunosuppression for penetrating keratoplasty and to evaluate the sensitivity of a high performance liquid chromatography coupled to electrospray mass spectrometry (LC-MS). High-risk penetrating keratoplasty was performed on 11 patients requiring 5 mg/kg of oral cyclosporin A and 9 patients with topical 0.5% (suspension, equivalent to 5 mg/ml)) preoperative immune suppression.