Worst case optimization for interfractional motion mitigation in carbon ion therapy of pancreatic cancer.

Introduction: The efficacy of radiation therapy treatments for pancreatic cancer is compromised by abdominal motion which limits the spatial accuracy for dose delivery - especially for particles. In this work we investigate the potential of worst case optimization for interfractional offline motion mitigation in carbon ion treatments of pancreatic cancer.

Methods: We implement a worst case optimization algorithm that explicitly models the relative biological effectiveness of carbon ions during inverse planning.