Glucose time series complexity as a predictor of type 2 diabetes.

Background: Complexity analysis of glucose profile may provide valuable information about the gluco-regulatory system. We hypothesized that a complexity metric (detrended fluctuation analysis, DFA) may have a prognostic value for the development of type 2 diabetes in patients at risk.

Methods: A total of 206 patients with any of the following risk factors (1) essential hypertension, (2) obesity or (3) a first-degree relative with a diagnosis of diabetes were included in a survival analysis study for a diagnosis of new onset type 2 diabetes.

[HIV infection in the adult: epidemiological changes over 25 years (1983-2008) in an area of the Community of Madrid].

Objective: To describe the epidemiological characteristics and evolution of a cohort of HIV-infected patients in Madrid (Spain) over a period of 25 years.

Methods: Longitudinal, prospective, cohort study of all patients diagnosed with HIV infection seen at the Hospital de Móstoles (1983-2008).

Results: Of the 2156 patients attended, 73% were men.

The route to diabetes: Loss of complexity in the glycemic profile from health through the metabolic syndrome to type 2 diabetes.

Aims: In many physiologic systems, the evolution from health to disease correlates with a loss of complexity in the system's output. We analyze the difference in complexity of the glycemic profile in healthy volunteers (H), patients with the metabolic syndrome (MS), and patients with type 2 diabetes mellitus (DM).

Methods: We measured interstitial fluid glucose every 5 minutes for 3 days in 10 H, 10 MS, and 10 DM.

Handgrip dynamometry in healthy adults.

Aims: To establish normal reference values for handgrip strength in healthy adult subjects using hand dynamometry.

Subjects And Methods: Descriptive study of 517 healthy volunteers (267 females and 229 males) aged 17-97 years. Grip strength was measured using two different handgrip dynamometers.