Antispasmodic, cardioprotective and blood-pressure lowering properties of L. and its mechanisms of action.

Background: L. is a native plant of South America whose pharmacological properties have not been studied yet.

Aim: To evaluate the cardiovascular and intestinal pharmacological effects of L.

Scientific diasporas and the advancement of science diplomacy: The InFEWS US-China program in the face of confrontational "" diplomacy.

The challenges and consequences of climate change have brought together governments around the world to advance scientific knowledge and programmatic actions to develop mitigation strategies while promoting sustainable development. The United States and China-the countries with the highest science expenditures globally-have historically developed a range of joint international research collaborations. However, under the " agenda put forth by the Trump Administration, bilateral diplomatic relations with China reached their highest confrontational peak.

[Mesencephalic Ewing sarcoma: Case report].

Ewing's sarcoma is a malignant neoplasm mainly occurring in the bone, with other locations being exceptional. In the case of primary intracranial presentations, it is essential to rule out metastatic lesions as well as other neuroectodermal tumors that may require different diagnostic and therapeutic approaches. We present a 14-year-old patient who consulted for upper eyelid ptosis of left eye associated with a 2-month history of diplopia, with imaging evidence of extra-axial tumor lesion, located at the level of the interpeduncular cistern.

Antispasmodic, antidepressant and anxiolytic effects of extracts from Marchand leaves.

(Anacardiaceae) is widely used in folk medicine for treating gastrointestinal and emotional complaints but there are no scientific studies that support these uses. This work aims at evaluating the antispasmodic and central effects of as well as the flavonoids presence in the tincture (SchT) and the composition of the essential oil (SchO). SchT inhibited the concentration-response curves (CRC) of carbachol and calcium in a non-competitive way in isolated rat intestine, bladder and uterus.

CBD-1 organizes two independent complexes required for eggshell vitelline layer formation and egg activation in C. elegans.

Metazoan eggs have a specialized coat of extracellular matrix that aids in sperm-egg recognition. The coat is rapidly remodeled after fertilization to prevent polyspermy and establish a more permanent barrier to protect the developing embryo. In nematodes, this coat is called the vitelline layer, which is remodeled into the outermost layer of a rigid and impermeable eggshell.

New similarity-based algorithm and its application to classification of anticonvulsant compounds.

A similarity-based algorithm based on a previously developed model is applied in the classification of two sets of anticonvulsant and non-anticonvulsant drugs. Each set is composed of a) anticonvulsant compounds that have shown moderate to high activity in the Maximal Electroshock Seizure (MES) test and b) drugs with other biological activities or poor activity in the MES test. The results from the analysis of variance (ANOVA) indicate that the proposed algorithm is able to differentiate anticonvulsant from non-anticonvulsant drugs.

Application of linear discriminant analysis in the virtual screening of antichagasic drugs through trypanothione reductase inhibition.

We have performed virtual screening to identify new lead trypanothione reductase inhibitor (TRI) compounds, enzyme present in Tripanozoma cruzi, the agent responsible of Chagas disease. From a training set of 58 compounds, linear discriminant analysis (LDA) was performed using 2D and 3D descriptors as discriminating variables in order to find out which function of descriptors characterizes the active TRI. The values of the statistical parameters F--Snedecor and Wilk's lambda for the discriminant function (DF) showed good statistical significance, as long as the rate of success in the prediction for both the training and the test set: 91.