Preliminary findings of a randomized controlled trial investigating the efficacy of transcranial magnetic stimulation in treatment-resistant depression: a analysis on the role of co-occurring personality disorders.

Introduction: Despite the high hopes for the use of transcranial magnetic stimulation (TMS) in the treatment of depression, between 30% and 60.5% of patients do not respond to stimulation. The factors contributing to non-response, especially those related to personality, remain insufficiently investigated.

Blunted Cortisol Awakening Response Is Associated with External Attribution Bias Among Individuals with Personality Disorders.

Background/objectives: The dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been associated with various mental disorders. One of the most commonly described parameters of HPA axis functioning is the cortisol awakening response (CAR). To date, few studies have been conducted on the relationship between personality disorders and CAR.

Felt presence and its determinants in young adults: results from three independent samples.

Felt presence (FP) is a phenomenon that might appear in individuals with mental and neurological disorders as well as those without any specific morbidity. Some studies have indicated that FP is closely related to psychotic symptomatology. Yet, the mechanisms underlying its occurrence remain largely unknown.

Evaluation of Intra- and Inter-Network Connectivity within Major Brain Networks in Drug-Resistant Depression Using rs-fMRI.

Major Depressive Disorder (MDD) is a significant challenge in modern medicine due to its unclear underlying causes. Brain network dysfunction is believed to play a key role in its pathophysiology. Resting-state functional MRI (rs-fMRI), a neuroimaging technique, enables the in vivo assessment of functional connectivity (FC) between brain regions, offering insights into these network dysfunctions.

The same but different too: Depression profiles in young adults without a history of psychiatric treatment identified using Bayesian and partial correlation networks.

Depression is a heterogenous diagnostic construct; however, dynamic interactions between specific depressive symptoms across their qualitatively different profiles remain largely unknown. The study aimed to recognize the most prevalent profiles of depressive symptoms and assess their dynamics in young adults without a history of psychiatric treatment. Depressive symptoms were recorded using the Patient Health Questionnaire-9 (PHQ-9).

Improvement of working memory in older adults with mild cognitive impairment after repetitive transcranial magnetic stimulation - a randomized controlled pilot study.

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique that could improve cognitive function. It is being developed as a non-pharmacological intervention to alleviate symptoms of cognitive deterioration. We assessed the efficacy of rTMS in improving cognitive functioning among people with Mild Cognitive Impairment (MCI) in a partially-blinded, sham-controlled randomized trial.

The Impact of the CYP2D6 and CYP1A2 Gene Polymorphisms on Response to Duloxetine in Patients with Major Depression.

Depression is a global mental health concern, and personalized treatment approaches are needed to optimize its management. This study aimed to investigate the influence of the CYP2D6 and CYP1A2 gene polymorphisms on the efficacy of duloxetine in reducing depressive and anxiety symptoms. A sample of 100 outpatients with major depression, who initiated monotherapy with duloxetine, were followed up.

Baseline depressive symptoms as predictors of efficacy and tolerability of the treatment with duloxetine: a network analysis approach.

Introduction: Depression is considered one of the most prevalent and burdensome mental disorders. Only 50-60% of patients respond to first-line treatment. Individuals with depression might benefit from personalized treatment, tailored to the individual needs of the patient.

Social Support Mediates the Association between Health Anxiety and Quality of Life: Findings from a Cross-Sectional Study.

This study aimed to test if perceived social support and cyberchondria mediate the association between health anxiety and quality of life (QoL) in a nonclinical sample. Cross-sectional research involved adult internet users ( = 538) between 16 May 2020 and 29 December 2020 in Poland who completed self-report questionnaires, including the cyberchondria severity scale (CSS-PL), the short health anxiety inventory (SHAI), the multidimensional scale of perceived social support (MSPSS) and the quality of life scale (QOLS). A mediation analysis was performed to examine the direct effects of health anxiety on cyberchondria, perceived social support and quality of life.

The Portrait of Cyberchondria-A Cross-Sectional Online Study on Factors Related to Health Anxiety and Cyberchondria in Polish Population during SARS-CoV-2 Pandemic.

The SARS-CoV-2 pandemic has served as a magnifying glass for cyberchondria, while the internet emerged as one of the main sources of medical information and support. The core ambition of this study was to estimate the level of cyberchondria and describe the socio-demographic, clinical and pandemic-related factors affecting its severity amid the SARS-CoV-2 pandemic. A cross-sectional study was performed between 16 May 2020 and 29 December 2020 in Poland within a sample of 538 adult internet users.

Does Mental Health Affect the Decision to Vaccinate Against SARS-CoV-2? A Cross-Sectional Nationwide Study Before the Vaccine Campaign.

The COVID-19 pandemic generated a sense of threat in the society, leading to social isolation and mental health deterioration. A great deal of hope for the development of herd immunity was placed in preventive vaccinations. The survey, performed before vaccine campaign between September 26-October 27, 2020, during the second wave of the SARS-CoV-2 pandemic in Poland with the Computer Assisted Web Interviews method.

Lifestyle Changes among Polish University Students during the COVID-19 Pandemic.

Students worldwide have been impacted by nationwide safety closures due to the COVID-19 pandemic, creating an environment with loss of interaction with colleagues, social isolation, boredom, and economic uncertainty. Since university students were considered uniquely vulnerable to mental health problems even before the pandemic, this study aimed to investigate lifestyle and behavioral changes experienced by this population due to the epidemiological situation and their effect on their mental health. Data were collected via an online survey conducted among university students across Poland.

Unknown Enemy and Psychopathological Responses: A Cross-Sectional Nationwide Study Assessing the Knowledge About COVID-19.

There is evidence that a lack of appropriate knowledge regarding global changes might be associated with various psychopathological responses. In this study, we tested the hypothesis that knowledge about COVID-19 correlates with the severity of psychopathological symptoms as measured by standardized questionnaires. The questionnaires were obtained using the Computer Assisted Web Interviews (CAWI) method during the second wave of the COVID-19 pandemic in Poland using the original COVID-19 knowledge questionnaire and the General Health Questionnaire-28 (GHQ-28).

Coping Strategies and Psychopathological Responses Among Medical and Non-medical Professionals - a Cross-Sectional Online Survey.

The SARS-CoV-2 pandemic was announced on March 11th, 2020, due to a surge of newly confirmed cases that significantly impacted populations worldwide, both directly and indirectly. Based on past epidemics research, the mental health implications of introduced restrictions should be expected and adequately addressed irrespective of the practiced profession. The study aimed to explore psychopathological responses, including post-traumatic stress disorder (PTSD), concerning coping strategy clusters during the COVID-19 pandemic among medical and non-medical workers.

Coping Styles, Mental Health, and the COVID-19 Quarantine: A Nationwide Survey in Poland.

The outbreak of the novel coronavirus COVID-19 that began from March 2020 is yet to be contained. Consequences of the ongoing pandemic may have a negative impact on the mental health of affected individuals. This particularly refers to those quarantined.

Mental Health of Medical and Non-Medical Professionals during the Peak of the COVID-19 Pandemic: A Cross-Sectional Nationwide Study.

Background: The study aimed to compare psychopathological expressions during the COVID-19 (novel coronavirus disease 2019) pandemic, as declared on March 11th 2020 by the World Health Organization, with respect to which institutional variables might distinguish the impact of COVID-19 in medical and non-medical professionals.

Methods: A cross-sectional study was performed nationwide between 16th March and the 26th April 2020 in Poland. A total of 2039 respondents representing all healthcare providers (59.

Is there any difference in acromegaly and other chronic disease in quality of life and psychiatric morbidity?

Introduction: The study aimed to evaluate the psychological profile of patients with acromegaly in comparison to other chronic diseases such as non-functioning pituitary adenomas, Cushing disease, and plaque psoriasis, and to a healthy control group.

Material And Methods: A total sample of 153 participants in clinical groups underwent a cross-sectional assessment including the quality of life (AcroQoL, WHOQoL-BREF), psychiatric morbidity (GHQ-28), and the acceptance of illness (AIS), as well as 65 participants in the healthy control group.

Results: The whole study sample had a predominance of urban married females (61%) with medium level of education (41%).

[The use of metabolomics in medicine - some examples of oncological and metabolic diseases].

Metabolomics is a new field of medicine focused on examining and analyzing metabolites produced in biological cells. Biological fluids primarily used in this method include: plasma, cerebrospinal fluid, saliva and urine. The most common methods of evaluating the composition involve nuclear magnetic resonance (NMR) and magnetic resonance (MR) with addition of gas chromatography (GC-MS) or liquid chromatography (LC-MS).