Publications by authors named "Julian Kraft"
Article Synopsis
- * Researchers developed a modified live influenza vaccine (MLIV) using a chimeric bat virus combined with surface proteins from a specific avian virus, which showed promising results after egg and chicken passaging.
- * The viral mutations discovered during testing improved safety profiles, as the adapted vaccine conferred strong protection in mice against lethal H5N1 infection, indicating potential for future mammalian vaccine applications.
The germinal centre is a dynamic microenvironment in which B cells that express high-affinity antibody variants produced by somatic hypermutation are selected for clonal expansion by limiting the numbers of T follicular helper cells. Although much is known about the mechanisms that control the selection of B cells in the germinal centre, far less is understood about the clonal behaviour of the T follicular helper cells that help to regulate this process. Here we report on the dynamic behaviour of T follicular helper cell clones during the germinal centre reaction.
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