Safety and Efficacy of Protamine Administration for Prevention of Bleeding Complications in Patients Undergoing TAVR.

Objectives: The aim of this study was to evaluate whether protamine administration for heparin reversal after transcatheter aortic valve replacement (TAVR) reduces bleeding complications and affects patient outcomes.

Background: Occurrence of major bleeding complications in patients undergoing TAVR is associated with increased morbidity and mortality.

Methods: This study included 873 patients undergoing TAVR, of whom 677 received protamine for heparin reversal.

Prognostic impact of cancer history in patients undergoing transcatheter aortic valve implantation.

Background: The benefit of TAVI in cancer patients is currently unclear.

Objectives: The purpose of this study is to investigate prognostic impact of cancer status (active cancer or previous cancer) in severe aortic stenosis (AS) patients undergoing transcatheter aortic valve implantation (TAVI).

Methods: Consecutive TAVI patients in the Heart Center Bonn were enrolled and we stratified the patients into three groups: current cancer (active cancer), non-current cancer (previous cancer), or no cancer.