A light-mediated cyclization reaction initiated by an atom transfer radical addition (ATRA) of haloalkanes onto alkenes was exploited for the synthesis of functionalized dihydrobenzofurans. Initial investigation indicated that the dimeric gold catalyst [Au(μ-dppm)Cl] can effectively be used for intermolecular ATRA reactions. Further, the reactivity was applied in a cascade-like cyclization for the preparation of dihydrobenzofuran derivatives.
View Article and Find Full Text PDFHerein, the development of a light-mediated synthesis of functionalized indolines and tetrahydroquinolines is reported. These structural motifs are considered as highly valuable targets, attributed to their widespread occurrence in pharmaceuticals and natural products. The gold-mediated approach offers a direct route to functionalized indolines in yields of up to 81% under mild photochemical conditions.
View Article and Find Full Text PDFThe preparation and reactivity of a range of novel paramagnetic chromium(II) complexes supported by a carbazole-based PNP pincer ligand is reported. Deprotonation of the ligand precursors (PNP)H () and subsequent reaction with chromium(II) chloride led to the formation of square-planar chlorido complexes (PNP)CrCl (). Further reaction with various alkylating agents resulted in the isolation of chromium alkyl complexes (PNP)CrR' () which were then hydrogenated to yield two rare examples of paramagnetic chromium(II) hydrides and .
View Article and Find Full Text PDF