Publications by authors named "Julian Elias Guggenberger"
Article Synopsis
- Node-positive non-small cell lung cancer (NSCLC) presents treatment challenges for patients unsuitable for concurrent chemoradiotherapy, leading to a study on the prognostic value of pretreatment PET parameters in high-risk patients receiving hypofractionated radiotherapy.
- A retrospective analysis of 42 patients from a single institution revealed median progression-free survival (PFS) of 11.5 months and overall survival (OS) of 24.3 months, with variables like SUVmax and ECOG performance status significantly predicting these outcomes.
- Multivariable analysis highlighted SUVmax as a key predictor for PFS and ECOG performance status for OS, with patients in the high total metabolic tumor volume (tMTV) group experiencing significantly poorer
Background: The objective of this study was to investigate the feasibility and efficacy of image-guided moderately hypofractionated thoracic radiotherapy (hypo-IGRT) in patients with non-small cell lung cancer (NSCLC) with poor performance status and severely limited pulmonary function and reserve.
Methods: Consecutive inoperable patients who had node-positive, stage IIB-IIIC (TNM, 8th edition) or recurrent NSCLC, had an Eastern Cooperative Oncology Group performance status ≥1, and had a forced expiratory volume in 1 second (FEV ) ≤1.0 L, had a single-breath diffusing capacity of the lung for carbon monoxide (DLCO-SB) ≤40% and/or on long-term oxygen therapy were analyzed.