Publications by authors named "Julian C K Tay"
Article Synopsis
- The study investigates the effectiveness and safety of pulsed field ablation (PFA) for treating atrial fibrillation (AF) in Asia, specifically focusing on its use for pulmonary vein isolation (PVI) and optional posterior wall ablation (PWA).
- A total of 101 AF patients were analyzed, revealing a 1-year atrial arrhythmia recurrence rate of 10% for paroxysmal AF and 21% for persistent AF, with no significant differences in efficacy between PVI-only and PVI + PWA approaches.
- The research concludes that PFA is a safe and effective method for AF ablation, with the additional PWA not leading to increased complications while maintaining procedural efficiency.*
Article Synopsis
- Catheter ablation is an effective treatment for supraventricular tachycardia (SVT), and this study investigates the impact of 3D-electroanatomic mapping (EAM) on fluoroscopy time during the procedure.
- Over 1750 SVT ablation cases were analyzed, finding that EAM leads to longer procedure times but significantly reduces fluoroscopy time (by about 20 minutes) and radiation exposure without increasing complications.
- The study noted that while fluoroscopy time decreased initially, this reduction plateaued after several years, suggesting that more experience with the technique may influence efficiency in complex cases.
Effect of Cangrelor on Infarct Size in ST-Segment-Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention: A Randomized Controlled Trial (The PITRI Trial).
Circulation
July 2024
Background: The administration of intravenous cangrelor at reperfusion achieves faster onset of platelet P2Y12 inhibition than oral ticagrelor and has been shown to reduce myocardial infarction (MI) size in the preclinical setting. We hypothesized that the administration of cangrelor at reperfusion will reduce MI size and prevent microvascular obstruction in patients with ST-segment-elevation MI undergoing primary percutaneous coronary intervention.
Methods: This was a phase 2, multicenter, randomized, double-blind, placebo-controlled clinical trial conducted between November 2017 to November 2021 in 6 cardiac centers in Singapore.
Background: Atrial fibrillation (AF) is a cause of serious morbidity such as stroke. Early detection and treatment of AF is important. Current guidelines recommend screening via opportunistic pulse taking or 12‑lead electrocardiogram.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates heart failure with mildly reduced ejection fraction (HFmrEF) in Asian populations, comparing it to heart failure patients with reduced (HFrEF) and preserved (HFpEF) ejection fractions.
- The research analyzed data from 16,493 patients admitted for heart failure from 2008 to 2014, focusing on characteristics like gender, age, and comorbidities, alongside all-cause mortality and hospitalizations up to December 2016.
- Findings reveal that HFmrEF patients have a lower mortality rate compared to HFrEF but a higher rate than HFpEF, indicating a unique clinical profile for HFmrEF, which sits between the two other types in terms of health outcomes
Introduction: Data on patients with small aortic annuli (SAA) undergoing transcatheter aortic valve implantation (TAVI) are limited. We aim to describe the impact of aortic annular size, particularly SAA and TAVI valve type on valve haemodynamics, durability and clinical outcomes.
Method: All patients in National Heart Centre Singapore who underwent transfemoral TAVI for severe symptomatic native aortic stenosis from July 2012 to December 2019 were included.
Article Synopsis
- The study examines how sex and diabetes mellitus (DM) affect Asian patients with heart failure with mildly reduced ejection fraction (HFmrEF), a condition where the heart's pumping ability is slightly impaired.
- It included 2,272 patients from 2008 to 2014, finding that more women had DM and differed in clinical characteristics compared to men, such as being older and having less coronary artery disease.
- While diabetes negatively impacted overall survival for both sexes, it was found to have a stronger association with adverse outcomes in women, emphasizing the need for tailored management approaches based on sex.
Background: Sudden cardiac arrest with or without sudden cardiac death (SCD) represents a heterogeneous spectrum of underlying etiology but is often a catastrophic event. Despite improvements in pre-hospital response and post-resuscitation care, outcomes remain grim. Thus, we aim to evaluate the predictors of survival in out-of-hospital cardiac arrests (OHCAs) and describe autopsy findings of those with the uncertain cause of death (COD).
View Article and Find Full Text PDFArticle Synopsis
- * A total of 22 patients, primarily elderly males with a mean age of 71.7 years, underwent the LBBP procedure, achieving an 86% success rate in lead implantation without major complications.
- * The findings indicate that the Agilis HisPro™ catheter, paired with the Tendril STS Model 2088TC lead, is a promising and safe method for performing LBBP.
Introduction: There are concerns that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may worsen the outcomes of patients with COVID-19. This systematic review and meta-analysis aimed to study the in-hospital mortality among COVID-19 patients who were on ACEIs/ARBs as compared to those not on ACEIs/ARBs.
Methods: We searched PubMed, EMBASE, clinicaltrials.
Catheter ablation for atrial fibrillation in a low-volume center using contemporary technology.
Int J Cardiol Heart Vasc
December 2020
Background: Catheter ablation is increasingly being performed worldwide for atrial fibrillation (AF). However, there are concerns of lower success rates and higher complications of AF ablations performed in low-volume centers. Thus, we sought to evaluate the safety and efficacy of AF catheter ablation in a low-volume center using contemporary technologies.
View Article and Find Full Text PDF