Publications by authors named "Julian Bursztyka"

Nowadays, research concerning immunomodulatory products are of great interest, particularly in the treatment of inflammatory diseases or the prevention of infectious diseases. These activities are usually evaluated on cell cultures, by tracking different factors requiring dedicated manipulation. Evaluation of the immunomodulatory activities of essential oils and pure compounds using several technics adapted to high content analysis is described in this study.

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Rationale: Concern for public health entails the need to evaluate the degree of exposure of population to toxicants. To do this, robust high-throughput approaches are required to be able to perform a large number of analyses in cohort studies. In this study, a data-filtering procedure was applied to mass spectral data acquired by direct analysis of biological fluids leading to rapid detection of metabolites in a model xenobiotic system.

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Vinclozolin is a dicarboxymide fungicide that presents antiandrogenic properties through its two hydrolysis products M1 and M2, which bind to the androgen receptor. Because of the lack of data on the biotransformation of vinclozolin, its metabolism was investigated in vitro in precision-cut rat liver slices and in vivo in male rat using [ (14)C]-vinclozolin. Incubations were performed using different concentrations of substrate, and the kinetics of formation of the major metabolites were studied.

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Article Synopsis
  • The study investigates how genistein, a compound with varying effects in different species, is metabolized in humans compared to rats, focusing on metabolic differences due to species variations.
  • Using radiolabeled genistein and various liver tissues, researchers identified multiple metabolites, finding similar hydroxylated products from both species, but different rates of metabolism.
  • The research highlights that in humans, conjugation reactions (adding molecules to genistein) are more prominent than oxidative reactions (chemical modifications), with a significant proportion of genistein converted into the glucuronide metabolite in both species.
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