Publications by authors named "Julian Baron"
Neuroinflammation and oxidative stress are conditions leading to neurological and neuropsychiatric disorders. Natural compounds exerting anti-inflammatory and anti-oxidative effects, such as Licochalcone A, a bioactive flavonoid present in a traditional Chinese herb (licorice), might be beneficial for the treatment of those disorders. Therefore, this study aimed to investigate the anti-inflammatory and anti-oxidative effects of Licochalcone A in LPS-activated primary rat microglia.
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- The study explores the impact of rice bran extract (RBE), rich in vitamin E and anti-inflammatory compounds, on activated microglia, which are linked to neurodegenerative diseases.
- RBE was found to significantly reduce the release of inflammatory molecules like PGE2 and also decreased the expression of pro-inflammatory markers while enhancing anti-inflammatory markers.
- The research indicates that RBE may have potential therapeutic effects in managing neuroinflammation by targeting specific signaling pathways in microglia.