Unusual Presentation of Conidiobolomycosis.

A 31-year-old gentleman, hailing from West Bengal, a farmer by occupation, with no known prior comorbidities, presented with a history of multiple painful swellings over the abdomen, thorax (back and front), and suprapubic region of 6 months' duration. The swelling started in the abdomen and subsequently involved the thorax. It also progressively increased in size over the 6 months.

Crystalloids in submandibular sialadenitis.

Fine needle aspiration cytology of the salivary glands plays an important role in the diagnosis of neoplastic and non neoplastic lesions of salivary gland. Crystalloids in salivary gland lesions are a rare occurrence. A case of submandibular sialomegaly in an elderly patient with a clinical suspicion of metastasis was subjected to FNAC which showed crystalloids morphologically resembling amylase occurring in a background of sialadenitis.

Vascular endothelial growth factor expression in ovarian serous carcinomas and its effect on tumor proliferation.

Introduction: Vascular endothelial growth factor (VEGF), an endothelial mitogen, acts through VEGF receptors (VEGFRs) on the endothelial cells. During neoplastic transformation, it is hypothesized that the tumor expresses VEGF and also acquire VEGF receptor, enabling VEGF action in an autocrine and paracrine manner with varied effects on the tumor growth and progression. This study on ovarian serous carcinomas (OSCs) was done to determine the expression of VEGF and to correlate it with tumor proliferation.

How accurate is intraoperative frozen section in the diagnosis of ovarian tumors?

Aim: The aim of this study was to evaluate the accuracy of intraoperative frozen section of ovarian tumors and to analyze the factors that influence the accuracy.

Material And Methods: We compared the frozen section diagnosis of 218 ovarian tumors with their final diagnosis in paraffin sections, over a period of 10 years from 1999 to 2008.

Results: Results were analyzed on two parameters: (i) status of malignancy and (ii) histological type.

Extraocular sebaceous carcinoma: a series of three cases with varied presentation.

Background: Extraocular sebaceous carcinomas are rare cutaneous malignancies that account for only about 25% of all sebaceous carcinomas. The most common site of occurrence is the head/neck region. They are aggressive neoplasms that possess metastatic potential to regional or distant sites.

Ovarian serous carcinoma: relationship of p53 and bcl-2 with tumor angiogenesis and VEGF expression.

The aim of the study was to assess the microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression in ovarian serous carcinoma and to examine their relation with apoptosis.Paraffin-embedded specimens of 41 cases of ovarian serous carcinomas were evaluated by immunohistochemistry for VEGF, p53, and bcl-2 expression. MVD was assessed with CD31 staining.

An unusual case of primary osteosarcoma of the rib in an adult.

Primary osteosarcomas are one of the most common malignant bone tumors principally affecting the long bones in children and adolescents. An unusual case of a primary osteoblastic osteosarcoma of the rib in a 42-year-old male is presented here. The patient underwent a wide excision of the tumor and chest wall reconstruction.

An immunohistochemical comparison of P53 and Bcl-2 as apoptotic and MIB1 as proliferative markers in low-grade and high-grade ovarian serous carcinomas.

Background: Traditionally, ovarian serous carcinomas (OSCs) have been graded using a 3-tiered system, as well differentiated, moderately differentiated, and poorly differentiated. Recently, a 2-tiered system has been proposed depending on the nuclear atypia and mitotic count. The dualistic pathway of ovarian serous carcinogenesis with accumulating molecular genetic evidence forms the basis for this grading system.

Pediatric malakoplakia of colon: a report of two cases.

Gastrointestinal system is the second most common site for the occurrence of malakoplakia. We report two cases of pediatric colonic malakoplakia with the endoscopic and characteristic histologic findings. Malakoplakia is rare in pediatric age group, no clinical and endoscopic findings are diagnostic and the condition can masquerade as other conditions like inflammatory bowel disease and tumors.

Significance of preoperative thrombocytosis in epithelial ovarian cancer.

Background: Reactive thrombocytosis is reported in a variety of solid tumors. A few studies have documented preoperative thrombocytosis in ovarian cancer and identified it as a marker of aggressive tumor biology.

Aim: To study the incidence of preoperative thrombocytosis (platelets greater than 400x10) in epithelial ovarian cancer and its association with other clinicopathologic factors.

An audit of cervicovaginal cytology in a teaching hospital: Are atypical glandular cells under-recognised on cytological screening?

Background: Cervical cytology screening for carcinoma of the cervix in India is mainly opportunistic in nature and is practiced mainly in urban centres. The effectiveness of cervical cytology screening depends on various factors. The quality of cervicovaginal cytology service is assessed by various quality indices and by cyto-histology correlation, which is the most important quality assurance measure.

Ovarian lymphoma.

The involvement of the ovary in lymphomatous processes is rare. Such an involvement can occur in 2 ways, either primary or secondary, which usually presents with abdominal or pelvic complaints. We present a case of secondary involvement of the ovary with occult extra-ovarian nodal disease and discuss the histogenesis of ovarian lymphomas with criteria for diagnosis and differential diagnosis.

Cytological features of lobular carcinoma of breast: how important are the intracytoplasmic lumina?

Lobular carcinoma is the most common pitfall in the cytodiagnosis of breast lesions. Of the cytological features described intracytoplasmic lumina are stressed by many authors as an important diagnostic feature. The present study aims at evaluating the importance of intracytoplasmic lumina in the cytodiagnosis of lobular carcinoma along with other cytological features.