Publications by authors named "Julia de Oliveira Xavier Ramos"
Severe COVID-19: understanding the role of immunity, endothelium, and coagulation in clinical practice.
J Vasc Bras
November 2020
SARS-CoV-2 is responsible for the COVID-19 pandemic. The immune system is a determinant factor in defense against viral infections. Thus, when it acts in a balanced and effective manner the disease is self-limited and benign.
View Article and Find Full Text PDFSevere acute respiratory syndrome coronavirus 2 infection is capable of affecting several organs. Direct viral toxicity, pro-inflammatory and pro-thrombotic induction, endothelial damage, immune imbalance, and dysregulation of the renin-angiotensin-aldosterone system are the mechanisms underlying the viral potential of multiple organ damage. The impairment of four organs stands out among severe patients: lung, heart, kidney, and endothelium.
View Article and Find Full Text PDFCOVID-19 and obesity are two pandemic diseases that the world is currently facing. Both activate the immune system and mediate inflammation. A sequence of disease phases in patients with severe COVID-19 results in a cytokine storm, which amplifies the subclinical inflammation that already exists in patients with obesity.
View Article and Find Full Text PDFIs Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?
Cytokine Growth Factor Rev
April 2021
Article Synopsis
- Severe COVID-19 is associated with a heightened immune response, especially in patients with conditions like obesity and diabetes, resulting in poor health outcomes.
- Chronic inflammation due to cardiometabolic issues leads to increased levels of pro-inflammatory cytokines like IL-6 and TNF-α, primarily through the Toll-Like Receptors 4 (TLR4) pathway.
- The spike protein of SARS-CoV-2 interacts with TLR4, triggering a severe immune reaction that can cause respiratory distress, cytokine storms, and potential damage to multiple organs.