Genome-wide association study of neocortical Lewy-related pathology.

Objective: Dementia with Lewy bodies is an α-synucleinopathy characterized by neocortical Lewy-related pathology (LRP). We carried out a genome-wide association study (GWAS) on neocortical LRP in a population-based sample of subjects aged 85 or over.

Methods: LRP was analyzed in 304 subjects in the Vantaa 85+ sample from Southern Finland.

Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly.

Introduction: Studies with strong selection biases propose that alpha-synucleinopathy (AS) spreads upwards and downwards in the neuraxis from the medulla, that amygdala-dominant AS is strongly associated with Alzheimer's disease (AD), and that a more severe involvement of the cerebral cortex is correlated with increasing risk of dementia. This study examines the association of AS patterns and observed neuropsychological symptoms in brains of a population-representative donor cohort.

Methods: Brains donated in 2 out of 6 cognitive function and ageing study cohorts (Cambridgeshire and Nottingham) were examined.

Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population.

Background: Behavioural and psychological symptoms of dementia (BPSD) are major contributors to the burden of dementia.

Aims: To describe the prevalence, correlates and course of BPSD in the population of England and Wales.

Method: The prevalence of 12 symptoms was estimated in 587 participants with dementia and 2050 participants without dementia as part of a population-based longitudinal study of ageing.

Population-based neuropathological studies of dementia: design, methods and areas of investigation--a systematic review.

Background: Prospective population-based neuropathological studies have a special place in dementia research which is under emphasised.

Methods: A systematic review of the methods of population-based neuropathological studies of dementia was carried out. These studies were assessed in relation to their representativeness of underlying populations and the clinical, neuropsychological and neuropathological approaches adopted.

A systematic review of prevalence and incidence studies of dementia with Lewy bodies.

Background: Substantial variation in the prevalence of Dementia with Lewy Bodies (DLB) has been reported with estimates ranging from 0 to 26.3% of all dementia cases, potentially making it the second most common dementia subtype.

Objectives: The aim of this study was to review systematically and critically for the first time previous studies of the clinical prevalence and incidence of DLB in the population.

A systematic review of prevalence studies of dementia in Parkinson's disease.

Substantial variation in the prevalence of dementia in Parkinson's disease (PDD) has been reported. The aim of this study was to review systematically and critically previous studies of the prevalence of PDD using PubMed to search the literature. Studies focusing on PD and PDD, as well as those examining on the epidemiology of dementia subtypes, were included.