Publications by authors named "Julia Worm"
Effects of Progesterone on Vasomotor Symptoms in Postmenopausal Women (PROGEST) - a Prospective Multi-Center Randomized Double-Blind Placebo-Controlled Trial (RDPCT).
Sissi Valentina Beinert Frauke Kleinsorge Julia Worm Katharina Victoria Tropschuh Vanadin Seifert-Klauss
Geburtshilfe Frauenheilkd
October 2024
Article Synopsis
- A Canadian trial found that oral micronized progesterone is more effective than placebo in reducing vasomotor symptoms (VMS) in postmenopausal women, with a dose-dependent improvement observed over 12 weeks.
- The study involved 74 women and tested three doses (200mg, 300mg, 400mg) of progesterone alongside placebo, but 44 participants dropped out, leading to a low final analysis group of 55.
- While most adverse events were minor, the trial's findings on VMS reduction were influenced by differences in study populations, with the placebo group showing a greater decline in VMS frequency than expected due to low participant accrual.