[Scleroderma-like skin changes following administration of paclitaxel for the treatment of ovarian carcinoma].

A 61-year-old women with ovarian carcinoma was treated with surgery followed by 6 cycles of paclitaxel (Taxol) and carboplatin, producing a complete remission. During the course of therapy, she developed diffuse cutaneous sclerosis and thickening along with edema, weight gain and malaise. While antinuclear antibodies were elevated, specific antibodies against Scl 70 were not found.