Publications by authors named "Julia Vieler"
Article Synopsis
- Circulating tumor cells and liquid biopsy markers could significantly influence cancer treatment decisions in the future.
- This study compares two reverse transcription enzymes, SuperScript IV VILO and Sensiscript, focusing on their effectiveness in detecting biomarkers in prostate cancer cell lines and clinical liquid biopsy samples.
- Results show that VILO outperforms SS, leading to more patients being correctly identified as biomarker-positive, which is crucial for effective clinical monitoring and treatment decisions.
Background: Research on prostate cancer is mostly performed using cell lines derived from metastatic disease, not reflecting stages of tumor initiation or early progression. Establishment of cancer cell lines derived from the primary tumor site has not been described so far. By definition, cancer cells are able to be cultured indefinitely, whereas normal epithelial cells undergo senescence in vitro.
View Article and Find Full Text PDFBackground: Androgen receptor (AR) splice variants (AR-Vs) have been discussed as a biomarker in prostate cancer (PC). However, some reports question the predictive property of AR-Vs. From a mechanistic perspective, the connection between AR full length (AR-FL) and AR-Vs is not fully understood.
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