Publications by authors named "Julia Vanini"
Article Synopsis
- - Changes in epigenetic processes like histone acetylation are important for the function and progression of pediatric brain tumors, with drugs like valproic acid (VPA) showing potential as anticancer therapies by inhibiting histone deacetylases (HDACs).
- - VPA treatment resulted in reduced viability of medulloblastoma (MB) cells, induced cell cycle arrest, and altered gene expression related to oncogenes and differentiation, alongside morphological changes that suggest neuronal differentiation.
- - The effects of VPA on MB cells included modifications in histone acetylation patterns that correlated with patient outcomes, suggesting its potential to influence clinical prognosis by targeting stemness and differentiation in specific MB subgroups.
Cytotoxicity, genotoxicity and mutagenicity of mixed ternary mononuclear Mg complex based on valproic acid with 1,10-phenanthroline in Saccharomyces cerevisiae and V79 cells.
Basic Clin Pharmacol Toxicol
December 2024
Article Synopsis
- Valproic acid (VA) is commonly used for treating central nervous system disorders and is being explored for anticancer applications, but it has notable side effects.
- Researchers studied a magnesium complex of valproate ([Mg(Valp)Phen]) and found it to be more cytotoxic than sodium valproate in both yeast and V79 cells.
- The increased toxicity of the magnesium complex may be linked to its ability to cause DNA damage, requiring various DNA repair pathways to fix the lesions it induces.
Glyphosate, the world's most widely used herbicide, has a low toxicity rating despite substantial evidence of adverse health effects. Furthermore, glyphosate-based formulations (GBFs) contain several other chemicals, some of which are known to be harmful. Additionally, chronic, and acute exposure to GBFs among rural workers may lead to health impairments, such as neurodegenerative diseases and cancer.
View Article and Find Full Text PDFObjective: This study evaluated the influence of smoking on the oral cells genotoxicity before and after at-home bleaching using 22% carbamide peroxide (CP).
Materials And Methods: This is a prospective observational analytics cohort study which evaluated nonsmokers (NS; n = 24) and smokers (S; n = 16) patients. At-home bleaching was performed using 22% CP gel in individual trays for 1 h per day for 14 days in both groups.
From 1992 to 2018, cytogenetic analyses were successfully performed to explore the chromosomal abnormalities of 729 patients, who utilised a pioneering counselling service in the city of Passo Fundo in the northern part of the Brazilian state of Rio Grande do Sul. This city is characterised by a large conglomerate of private and public hospitals. A classical cytogenetic analysis and G-banding were performed using the patient samples.
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