Publications by authors named "Julia Trudeau"
Chronic dysregulation of microglial phenotypic balance contributes to prolonged neuroinflammation and neurotoxicity, which is a hallmark of neurodegenerative diseases. Thus, targeting microglial inflammatory signaling represents a promising therapeutic strategy for neurodegenerative diseases. Regulator of G protein Signaling 10 (RGS10) is highly expressed in microglia, where it suppresses pro-inflammatory signaling.
View Article and Find Full Text PDFWe examined the effect of alcohol consumption and smoking on the abundance of drug-metabolizing enzymes and transporters (DMET) in human liver microsomes (HLM) isolated from liver tissues of 94 donors. Global proteomics analysis was performed and DMET protein levels were analyzed in relation to alcohol consumption levels, smoking history, and sex using non-parametric tests (p-value ≤ 0.05; cutoff of 1.
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- Exemestane (EXE) is a treatment for postmenopausal women with estrogen receptor-positive breast cancer, and its metabolism mainly occurs through glutathione-S-transferase (GST) enzymes.
- A study investigated the impact of genetic variations in these GST enzymes on EXE metabolism, finding that certain genotypes significantly affected EXE and its metabolites in liver samples and plasma of patients.
- Results indicated that the GSTA1 *B*B genotype is linked to variations in EXE metabolism, influencing treatment responses among individuals undergoing therapy for ER+ breast cancer.