Publications by authors named "Julia T Ullmann"
TGF-β1 is known to have a pro-inflammatory impact by inducing Th9 and Th17 cells, while it also induces anti-inflammatory Treg cells (Tregs). In the context of allergic airway inflammation (AAI) its dual role can be of critical importance in influencing the outcome of the disease. Here we demonstrate that TGF-β is a major player in AAI by driving effector T cells, while Tregs differentiate independently.
View Article and Find Full Text PDFBackground: Several microRNAs (miRs) have been described as potential biomarkers in liquid biopsies and in the context of allergic asthma, while therapeutic effects on the airway expression of miRs remain elusive. In this study, we investigated epigenetic miR-associated mechanisms in the sputum of grass pollen-allergic patients with and without allergen-specific immunotherapy (AIT).
Methods: Induced sputum samples of healthy controls (HC), AIT-treated and -untreated grass pollen-allergic rhinitis patients with (AA) and without asthma (AR) were profiled using miR microarray and whole-transcriptome microarray analysis of the same samples.
Article Synopsis
- This study investigates how allergen exposure affects T 2 cell exhaustion during allergen-specific immunotherapy (AIT), focusing on mice and human patient cohorts.
- Results show that proallergic T 2 cells increase exhaustion markers (CTLA-4 and PD-1) after allergen exposure but decrease after AIT, especially in local lung T 2 cells.
- The findings highlight a difference in T 2 cell exhaustion patterns during AIT's up-dosing and maintenance phases, suggesting prolonged effects of treatment on T 2 cell populations.