Publications by authors named "Julia Sophie Onken"
Background: Spine surgical training faces increasing challenges due to restricted working hours and greater sub specialization. Modern simulators offer a promising approach to teaching both simple and complex spinal procedures. This study evaluated the acceptance and efficacy of spine simulator training using a lumbar herniated disc model tested by 16 neurosurgical residents (PGY-1-6), and compared 3D and 2D teaching methods.
View Article and Find Full Text PDFBackground: Surgical site infections (SSIs) account for one of the most common causes of nosocomial infections. Bundle approaches for infection prevention and control do not capture the full complexity of neurosurgical interventions.
Objective: To study the efficacy of an interdisciplinary infection prevention and control bundle (IPCB) in neurosurgery.
Article Synopsis
- The study investigates the use of prostate specific membrane antigen (PSMA) as a target for treating high-grade gliomas (HGG) with radioligand therapy, specifically [Lu]Lu-PSMA RLT.
- Researchers assessed patients' eligibility by performing [Ga]Ga-PSMA PET/MRI scans and comparing tumor PSMA expression to treatment outcomes.
- Results showed that only 15% of patients qualified for [Lu]Lu-PSMA RLT, and the correlation between PSMA expression in blood vessels and PET/MRI uptake suggests potential for using this as a patient screening method in future studies.
Object: Recent studies demonstrated that gross total resection of brain metastases cannot always be achieved. Subtotal resection (STR) can result in an early recurrence and might affect patient survival. We initiated a prospective observational study to establish a MRI-based risk assessment for incomplete resection of brain metastases.
View Article and Find Full Text PDFThe receptor tyrosine kinase AXL (RTK-AXL) is implicated in therapy resistance and tumor progression in glioblastoma multiforme (GBM). Here, we investigated therapy-induced receptor modifications and how endogenous RTK-AXL expression and RTK-AXL inhibition contribute to therapy resistance in GBM. GBM cell lines U118MG and SF126 were exposed to temozolomide (TMZ) and radiation (RTX).
View Article and Find Full Text PDFObjective: The utilization of fluorescein-guided biopsies and resection has been recently discussed as a suitable strategy to improve and expedite operative techniques for the resection of central nervous system (CNS) tumors. However, little is known about the optical properties of sodium fluorescein (NaFl) in human tumor tissue and their potential impact on analyses involving fluorescence-based methods.
Methods: Tumor tissue was obtained from a study cohort of an observational study on the utilization of fluorescein-guided biopsy and resection (n=5).