Publications by authors named "Julia Silva Cantoni"
Immunol Invest
November 2024
Article Synopsis
- Recent studies have shifted focus from the NLRP3 receptor and innate immune cells to NLRP1's role in CD4+ T cell dysregulation in people living with HIV (PLWH), potentially increasing chronic inflammation.
- Researchers assessed NLRP1 activation in CD4+ T cells using various stimulation methods, discovering that PLWH T cells showed a heightened response.
- The presence of functional variants in NLRP1 correlated with greater inflammatory dysregulation, leading to increased IL-1β release and pyroptosis in PLWH, which may contribute to chronic inflammation and related diseases.
