Dominant B-cell epitopes from cancer/stem cell antigen SOX2 recognized by serum samples from cancer patients.

Human sex determining region Y-box 2 (SOX2) is an important transcriptional factor involved in the pluripotency and stemness of human embryonic stem cells. SOX2 plays important roles in maintaining cancer stem cell activities of melanoma and cancers of the brain, prostate, breast, and lung. SOX2 is also a lineage survival oncogene for squamous cell carcinoma of the lung and esophagus.

Cardiac involvement secondary to mediastinal lymphoma in a cat: regression with chemotherapy.

Mediastinal lymphoma with neoplastic invasion into the heart was diagnosed in a 9-year-old castrated male domestic short hair cat. The neoplastic infiltrate was seen throughout the atria and atrial septum, surrounded the aortic root, and resulted in narrowing of the right ventricular outflow tract. Chemotherapy resulted in resolution of the echocardiographic abnormalities and the cat's clinical signs until the patient was euthanized 58 days later following development of neurologic signs.

Chronic hepatitis in Labrador Retrievers: clinical presentation and prognostic factors.

Background: An increased incidence of chronic hepatitis has been reported in Labrador Retrievers.

Hypothesis: A breed associated hepatopathy occurs in Labrador Retrievers.

Animals: Twenty-four client-owned Labrador Retrievers.