Publications by authors named "Julia Serrano-Lobo"
Article Synopsis
- The COVID-19 pandemic led to a noticeable increase in catheter-related bloodstream infections (C-RBSI) at a large hospital, prompting the need to assess trends and causes over a five-year period from 2018 to 2023.
- A total of 556 C-RBSI episodes were analyzed, revealing fluctuating incidence rates, with the peak occurring during the pandemic year of 2020, and a slight decline in subsequent years.
- The study found that most C-RBSI cases were linked to coagulase-negative Staphylococci, but there was a significant increase in infections caused by Gram-negative bacteria post-pandemic.
Article Synopsis
- The study assessed the impact of omitting the filtration and inoculum adjustment steps in the E.Def 10.2 method for screening azole resistance, using 98 fungal isolates previously classified as either azole susceptible or resistant.
- Analysis showed that skipping these steps did not significantly affect the agreement rates for azole screening, achieving high agreements for various antifungal drugs (itraconazole at 99%, voriconazole at 100%, and posaconazole at 94.9%).
- Overall, the use of unfiltered and unadjusted conidial suspensions maintained perfect sensitivity and specificity for determining resistance, confirming that these modifications optimize the azole resistance screening process.
Introduction: The epidemiological evolution of bloodstream infections (BSIs) in the last decade is not clearly defined. Our aim was to analyze the changes in the workload in our institution and to describe the evolution of the incidence and etiology of BSIs in a 12-year period, including the COVID-19 pandemic.
Methods: All blood cultures received in the laboratory of a tertiary general hospital between 2010 and 2021 were analyzed.
Fourier-transform infrared (FTIR) spectroscopy has the potential to be used for bacterial typing and outbreak characterization. We evaluated FTIR for the characterization of an outbreak caused by Elizabethkingia miricola. During the 2020-2021 period, 26 isolates (23 clinical and 3 environmental) were collected and analyzed by FTIR (IR Biotyper) and core-genome MLST (cgMLST), in addition to antimicrobial susceptibility testing.
View Article and Find Full Text PDFBackground: Studies comparing gradient diffusion strips (GDSs) and the EUCAST E.Def 9.4 microdilution method are scarce, thwarted by a low number of isolates, and restricted to selected antifungal agents.
View Article and Find Full Text PDFBackground: Azole resistance screening in A. fumigatus isolates can be routinely carried out by using azole-containing plates (E.Def 10.
View Article and Find Full Text PDFUnlabelled: We recently reported high essential (97.1%) and categorical (99.6%) agreements between azole and amphotericin B MICs against Aspergillus fumigatus sensu lato obtained by visual and spectrophotometric readings using a ≥ 95% fungal growth endpoint and following the EUCAST methodology (doi: 10.
View Article and Find Full Text PDFAzole-containing agar is used in routine Aspergillus fumigatus azole resistance screening. We evaluated the impact of the type of plastic used to prepare in-house agar plates on the procedure's performance against A. fumigatus sensu stricto and cryptic species.
View Article and Find Full Text PDFMice lacking a microbiota are protected from diet-induced obesity. Previous studies have shown that feeding a Western diet causes hypothalamic inflammation, which in turn can lead to leptin resistance and weight gain. Here, we show that wild-type (WT) mice with depleted gut microbiota, i.
View Article and Find Full Text PDFThe EUCAST EDef 9.3.2 procedure recommends visual readings of azole and amphotericin B MICs against spp.
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