Publications by authors named "Julia Schnell"
Classic regulatory T (T) cells expressing CD4 and the hallmark transcription factor FOXP3 are integral to the prevention of multi-system autoimmunity. However, immune-mediated arthritis is often associated with increased numbers of T cells in the inflamed joints. To understand these seemingly conflicting observations, which we collectively describe as 'the T paradox', we provide an overview of T cell biology with a focus on T cell heterogeneity, function and dysfunction in arthritis.
View Article and Find Full Text PDFThe antiapoptotic protein BCL2A1 is highly, but very heterogeneously expressed in Diffuse Large B-cell Lymphoma (DLBCL). Particularly in the context of resistance to current therapies, BCL2A1 appears to play an important role in protecting cancer cells from the induction of cell death. Reducing BCL2A1 levels may have therapeutic potential, however, no specific inhibitor is currently available.
View Article and Find Full Text PDFObjective: The aim of this study was to examine the influence of work-related behavior and experience patterns on sleep quality in emergency medical service personnel.
Methods: From the total sample of 508 emergency medical service workers who took part in the Germany-wide online survey, 368 respondents completed the questionnaires on sleep characteristics (Pittsburgh Sleep Quality Index [PSQI]) and work-related behavior and experience pattern. Three hundred sixty-seven of the 368 participants also finished the Regensburg Insomnia Scale.
Background: The workloads of emergency medical service personnel (EMS) are varied. In the absence of recovery, health consequences can result. The aim of this review was to analyze the literature on the associations between psychosocial or physical work factors on one hand and the well-being outcomes and job satisfaction on the other hand.
View Article and Find Full Text PDFArticle Synopsis
- IL-1β is a proinflammatory molecule that plays a key role in both innate and adaptive immune responses, and it significantly contributes to autoimmune arthritis by enhancing the bone-resorbing ability of regulatory T cells (Tregs).
- Research using mice lacking the IL-1 receptor antagonist showed that blocking IL-1β was more effective in reducing early arthritis symptoms and bone damage than treating established cases.
- The study found that Tregs in inflamed joints had altered behavior, producing RANKL, which promotes bone erosion, and similar T cells were identified in human rheumatoid arthritis, linking IL-1β activity to joint damage.