Publications by authors named "Julia Schermuly"
Article Synopsis
- Marek's disease virus (MDV) causes serious health issues like immunosuppression and lymphoma in chickens, primarily affecting their lymphoid organs, particularly B-cells in the bursa of Fabricius.
- The study reveals that MDV infection enhances the survival of bursal B-cells while significantly down-regulating genes related to cytokines, cell cycle, and apoptosis, suggesting a change in cellular behavior.
- Ultimately, MDV-infected B-cells exhibit characteristics resembling cellular senescence, resulting in longer cell lifespan, providing valuable insights into the virus's impact on these immune cells.
We estimated the dynamic cell metabolic activity and the distribution of the pH value and oxygen concentration in tissue samples cultured in vitro by using real-time sensor records and a numerical simulation of the underlying reaction-diffusion processes. As an experimental tissue model, we used chicken spleen slices. A finite element method model representing the biochemical processes and including the relevant sensor data was set up.
View Article and Find Full Text PDFMarek's disease virus (MDV) is an alphaherpesvirus that causes deadly T-cell lymphomas in chickens and serves as a natural small animal model for virus-induced tumor formation. In vivo, MDV lytically replicates in B cells that transfer the virus to T cells in which the virus establishes latency. MDV also malignantly transforms CD4+ T cells with a T(reg) signature, ultimately resulting in deadly lymphomas.
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