Publications by authors named "Julia Rimboeck"
HELLP syndrome is characterized by hemolysis, elevated liver enzymes, and a low platelet count and poses an increased risk to the pregnant woman and the unborn child. Individual risk factors such as obesity may alter immunocompetence and influence the course of preeclampsia (PE) or HELLP syndrome. Blood samples were collected from 21 pregnant women (7 healthy, 6 with PE, and 8 with HELLP syndrome) and polymorphonuclear neutrophils (PMNs) were subsequently isolated.
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- Centrifugation, a common method for isolating neutrophils, may negatively impact their functionality, suggesting prior research could be biased.
- Researchers hypothesized that gently isolated neutrophils, instead of undergoing NETosis, actually exhibit a natural process of apoptosis over time.
- Through live-cell imaging, it was found that neutrophils can retain significant migratory activity for over six days when isolated without centrifugation, indicating the importance of using native cells in future studies.