Publications by authors named "Julia Oldenburg"
4,4'-Isopropylidenediphenol (bisphenol A, BPA), a chemical substance that is widely used mainly as a monomer in the production of polycarbonates, in epoxy resins, and in thermal papers, is suspected to cause epigenetic modifications with potentially toxic consequences. Due to its negative health effects, BPA is banned in several products and is replaced by other bisphenols such as bisphenol S and bisphenol F. The present study examined the effects of BPA, bisphenol S, bisphenol F, ,'-oxybisphenol, and the BPA metabolite BPA β-d-glucuronide on the expression of a set of microRNAs (miRNAs) as well as methylation in human lung fibroblast and Caco-2 cells.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on the effects of various bioactive compounds on the inflammation related to senescent (aging) preadipocytes, which are fat cells, and how these compounds may modulate harmful signaling in obesity.
- Various methods were used, including treating cells with bromodeoxyuridine to induce senescence, measuring specific enzyme activity, and analyzing cytokine levels to assess inflammation changes.
- Results indicated that compounds like EGCG and resveratrol demonstrated potential to reduce inflammation markers and affect cell aging, suggesting they could be beneficial in managing obesity-related inflammation.