Publications by authors named "Julia Neufeld"
Article Synopsis
- Successful human pregnancy relies on the deep invasion of extravillous trophoblast cells (EVTs) into the maternal decidua, influenced by local signaling in the microenvironment.
- Trophoblast spheroids were studied on both undifferentiated and decidualized endometrial stromal cells (ESC), revealing that decidualized ESC significantly enhance trophoblast expansion compared to undifferentiated ESC.
- Key factors like HB-EGF and IL-1β were found to boost trophoblast cell behavior, indicating that decidualized ESC provide essential paracrine signals necessary for effective trophoblast invasion during early pregnancy.
Objective: The goal of this study was to determine the maximal tolerated dose (MTD) of topotecan given with external-beam radiotherapy in advanced cervical cancer.
Methods: A prospective Phase I trial of topotecan given with standard external-beam radiotherapy was performed in patients with advanced squamous cell carcinoma of the cervix. Patients were treated with a starting dose of 0.