Temporal lobe volume changes in people at high risk of schizophrenia with psychotic symptoms.

Background: Magnetic resonance imaging (MRI) has demonstrated abnormalities of brain structure, particularly of the temporal lobes, in schizophrenia. These are thought to be neurodevelopmental in origin, but when they become evident is unknown.

Aims: To determine if temporal lobe volumes reduce during the development of symptoms of schizophrenia in initially well people at high risk of this disorder.