Testing visual self-misperception in anorexia nervosa using a symmetrical body size estimation paradigm.

Objective: Individuals diagnosed with anorexia nervosa (AN) often report seeing themselves as overweight. While body size estimation tasks suggest that such individuals overestimate their body size, these tasks have failed to establish whether this misestimation stems from visual misperception. Misestimation might, instead, be due to response bias.

Null Effect of Olfactory Training With Patients Suffering From Depressive Disorders-An Exploratory Randomized Controlled Clinical Trial.

Unlabelled: Due to a close functional relation between brain areas processing emotion and those processing olfaction, major depression is often accompanied by reduced olfactory function. Such hyposmia can be improved by regular olfactory training (OT) over several months. As this training furthermore improves subjective well-being, we explored whether OT is a useful complementary strategy for depression treatment.

Individual Significance of Olfaction: A Comparison Between Normosmic and Dysosmic People.

Background: Olfactory dysfunction is common in older individuals. The importance of such dysfunction to individuals is highly variable: many people do not seem to care about their olfactory dysfunction, others suffer and complain about problems in daily life, a reduced quality of life, or symptoms of depression.

Objective: Understanding the importance of olfaction for different age groups in normosmic as well as in smell-disordered subjects may help to find reasons for insufficient coping with olfactory dysfunction.

Altered Medial Frontal Feedback Learning Signals in Anorexia Nervosa.

Background: In their relentless pursuit of thinness, individuals with anorexia nervosa (AN) engage in maladaptive behaviors (restrictive food choices and overexercising) that may originate in altered decision making and learning.

Methods: In this functional magnetic resonance imaging study, we employed computational modeling to elucidate the neural correlates of feedback learning and value-based decision making in 36 female patients with AN and 36 age-matched healthy volunteers (12-24 years). Participants performed a decision task that required adaptation to changing reward contingencies.

Partially restored resting-state functional connectivity in women recovered from anorexia nervosa.

Background: We have previously shown increased resting-state functional connectivity (rsFC) in the frontoparietal network (FPN) and the default mode network (DMN) in patients with acute anorexia nervosa. Based on these findings we investigated within-network rsFC in patients recovered from anorexia nervosa to examine whether these abnormalities are a state or trait marker of the disease. To extend the understanding of functional connectivity in patients with anorexia nervosa, we also estimated rsFC between large-scale networks.

Brain parcellation choice affects disease-related topology differences increasingly from global to local network levels.

Network-based analyses of deviant brain function have become extremely popular in psychiatric neuroimaging. Underpinning brain network analyses is the selection of appropriate regions of interest (ROIs). Although ROI selection is fundamental in network analysis, its impact on detecting disease effects remains unclear.