Publications by authors named "Julia Morimoto"
Article Synopsis
- BCC (Burkholderia cepacia complex) is a significant cause of pneumonia, particularly in cystic fibrosis patients, and has also been seen in those without cystic fibrosis, with a notably high mortality rate.
- Combination antibiotic therapy has shown promise in treating BCC pneumonia, yet there's little information regarding its effectiveness for initial and recurring infections.
- A case study highlights successful treatment of a non-cystic fibrosis patient with BCC pneumonia using a mix of intravenous, inhalational, and oral antibiotics, suggesting that early diagnosis and prompt combination therapy, including inhaled tobramycin, can be effective in managing recurrent BCC infections.
Article Synopsis
- - The study focused on identifying risk factors for COVID-19 deterioration in unvaccinated individuals under 65 years old during Japan's fifth wave, as many cases occurred in this demographic.
- - Researchers analyzed data from 1,675 patients in Fukushima and created predictive scores to estimate deterioration risk using logistic regression, highlighting significant factors like age, body temperature, oxygen saturation, and comorbidities (diabetes, obesity).
- - The findings indicated that 8.6% of patients experienced deterioration, with predictors including older age, male gender, and various health issues; two risk scores were developed, DOATS and DOAT, to assess patient risk.
Article Synopsis
- A study was conducted to evaluate the efficacy of molnupiravir in hospitalized patients with mild-to-moderate COVID-19 during the Omicron variant surge in Fukushima, Japan, by comparing outcomes between those who used the drug and those who did not.
- After matching molnupiravir users with non-users based on similar characteristics, results showed that the clinical deterioration rate was significantly lower for users (3.90%) compared to non-users (8.40%).
- Multivariate analysis indicated that treatment with molnupiravir independently reduced the risk of deterioration in COVID-19 patients after hospitalization during the Omicron variant phase.
Article Synopsis
- - The study assessed the effectiveness of the monoclonal antibody treatment casirivimab-imdevimab for mild-to-moderate COVID-19 patients during the Delta variant surge in Fukushima, Japan, enrolling 949 patients.
- - Casirivimab-imdevimab users were generally older and had higher rates of health issues like obesity, hypertension, and higher body temperatures compared to non-users.
- - The findings show that receiving casirivimab-imdevimab significantly reduced the risk of clinical deterioration in hospitalized patients, highlighting its potential benefit during COVID-19 hospitalization (odds ratio 0.448).
Background: Inflammatory myositis, such as dermatomyositis, is sometimes complicated by cancer and is recognized as cancer-associated myositis. Although some autoimmune antibodies are considered to be involved in the development of myositis in cancer patients, the precise mechanism has not been clarified. The findings of the present case shed light on the mechanism by which anti-transcriptional intermediary factor 1 (TIF1)-γ Ab was produced and the pathogenesis of cancer-associated myositis.
View Article and Find Full Text PDFObjective: Fractional exhaled nitric oxide (FeNO) is considered to be an adjunct for asthma management, although its usefulness remains controversial. Therefore, it may be necessary for new approaches to use FeNO for asthma management. We evaluated whether diurnal variations of FeNO can predict response to asthma treatment.
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- A case study highlights the successful use of high-dose intravenous immunoglobulin (IVIg) treatment in a patient with severe COVID-19, leading to significant improvement in lung inflammation despite prior clinical deterioration.
- The deterioration was attributed to the reactivation of proinflammatory factors (like tumor necrosis factor-α and interleukin-6), not just the viral presence.
- IVIg may help manage severe COVID-19 by suppressing the immune response and inhibiting harmful cytokines, potentially countering the cytokine storm associated with SARS-CoV-2 infection.
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a primary intestinal T-cell lymphoma and other organ involvement is very rare. A rare case of MEITL involving the lung and brain is herein reported. The patient developed panperitonitis with a small intestinal perforation, and emergency surgery was performed.
View Article and Find Full Text PDFBackground: Hypothyroidism was recently reported to be common and to predict mortality in patients with idiopathic pulmonary fibrosis (IPF). In addition, a high prevalence of hypothyroidism was shown in patients with idiopathic pleuroparenchymal fibroelastosis. However, in idiopathic interstitial pneumonia (IIP), a clinical significance of thyroid function has not been clarified in detail.
View Article and Find Full Text PDFObjectives: Thrombotic thrombocytopenic purpura (TTP) is a rare form of thrombotic microangiopathy. In recent years, an extensive variety of drugs, including certain cytotoxic agents, have been reported to be associated with TTP. Additionally, several studies have reported that granulocyte colony-stimulating factor (G-CSF) was produced by lung carcinoma.
View Article and Find Full Text PDFWe report a case of eosinophilic granulomatosis with polyangiitis (EGPA) complicated with a IgG4 related disease like symptoms presenting as eyelid swellings. In the present case, the serum level of IgG4 and the ratio of IgG4 to IgG were generally increased by the disease course of EGPA. Considering the course of clinical symptoms, there is a possibility that orbital manifestations were one of the clinical features during the disease course of EGPA while the histological features of right eyelid tissue and other ocular manifestations were consistent with the diagnosis of IgG4 related disease.
View Article and Find Full Text PDFBackground: Decorin is a small leucine-rich repeat proteoglycan that plays a critical role in collagen fibrillogenesis, and regulates inflammation, wound healing and angiogenesis. In idiopathic pulmonary fibrosis (IPF), decorin is expressed in fibrotic lesions; furthermore, intratracheal gene transfer of decorin has been demonstrated to inhibit bleomycin-induced pulmonary fibrosis. Although these results suggest the critical role of decorin in pulmonary fibrosis, the role of decorin in the acute exacerbation of idiopathic interstitial pneumonia (AE-IIP) has not been clarified in detail.
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