Publications by authors named "Julia Mayrink"
Article Synopsis
- Intestinal γδ T cells help keep the gut healthy and affect how the brain works and our behavior.
- Mice without these cells showed strange, repetitive behaviors that depended on the bacteria in their guts.
- By changing the bacteria in the mice, scientists discovered how these T cells connect gut health to brain behavior, showing the importance of gut bacteria and their chemicals.
Emerging evidence suggests that dysregulation of neuroinflammation, particularly that orchestrated by microglia, plays a significant role in the pathogenesis of Alzheimer's disease (AD). Danger signals including dead neurons, dystrophic axons, phosphorylated tau, and amyloid plaques alter the functional phenotype of microglia from a homeostatic (M0) to a neurodegenerative or disease-associated phenotype, which in turn drives neuroinflammation and promotes disease. Thus, therapies that target microglia activation constitute a unique approach for treating AD.
View Article and Find Full Text PDFBackground: Gamma-delta (γδ) T cells are a major cell population in the intestinal mucosa and are key mediators of mucosal tolerance and microbiota composition. Little is known about the mechanisms by which intestinal γδ T cells interact with the gut microbiota to maintain tolerance.
Results: We found that antibiotic treatment impaired oral tolerance and depleted intestinal γδ T cells, suggesting that the gut microbiota is necessary to maintain γδ T cells.