Publications by authors named "Julia Mastouri"
Proc Natl Acad Sci U S A
February 2019
Article Synopsis
- Mutations in RAS genes, common in human cancers, keep the RAS protein in an active state, promoting cancer growth.
- Targeting guanine nucleotide exchange factors like SOS1 can reduce active RAS levels by disrupting its interaction with RAS.
- The study introduces a small-molecule inhibitor (BAY-293) that effectively blocks the KRAS-SOS1 complex, showing potent anticancer activity with a low inhibitory concentration.
