Publications by authors named "Julia Lehman"
Current validated lichen planus (LP) scoring systems are complicated and optimized for generalized, multi-site disease. There is a need for a validated, simple lesional assessment in LP. Herein, we repurpose and optimize the modified Composite Assessment of Index Lesion Severity (mCAILS) for LP and to validate the optimized lichen planus CAILS (lpCAILS).
View Article and Find Full Text PDFBackground: Controversy exists around the optimal timing of resection of nevus sebaceous (NS). The authors aim to determine optimal timing of NS resection and identify predictors of surgical outcomes and secondary intralesional neoplasms.
Methods: Retrospective chart review of all patients with biopsy-proven NS diagnosis treated at the authors' institution between 1987 and 2024.
Purpose: To review cases of lateral brow dermoid cysts and gain insight into the utility of preoperative imaging, incidence of intraorbital extension, and recurrence rate.
Methods: This is a retrospective study of all patients who underwent excision of lateral brow dermoid cysts at the authors' academic center over a 37-year period.
Results: A total of 136 patients were included.
Background: Maculopapular cutaneous mastocytosis (MPCM) is a rare disorder characterized by a pathologic accumulation of mast cells in the skin, which may or may not be accompanied by systemic mastocytosis. Diagnosis of MPCM on skin biopsy can be challenging because the findings may be subtle. Although mast cell density in MPCM has been reported, data informing a proposed cutoff for diagnosis and diagnostic criteria are limited.
View Article and Find Full Text PDFObjective: Dermoid cyst (DC) is a congenital cyst with the potential to have intracranial extension (ICE). This study aims to evaluate the imaging yield and surgical outcomes of nasal, medial brow, forehead, and scalp DCs.
Design: Retrospective review of craniofacial DCs treated at our institution between 1992 and 2024.
Article Synopsis
- The study investigates porokeratosis localized to the penis and scrotum, analyzing data from patients diagnosed between 2000 and 2022.
- Nine patients were included, with a median age of 51, and most had either penile or scrotal lesions, while one had extensive lesions affecting multiple areas.
- The findings indicate that clinical diagnosis can be challenging and highlights the importance of histopathological examination, as follow-ups showed no recurrence or malignant transformation in patients after biopsy removal.
Article Synopsis
- Drug repurposing offers a cost-effective strategy for developing therapies for rare diseases, which often face challenges in traditional drug development.
- This study used a new drug identification and repurposing pipeline to discover molecular drivers and potential therapies for psoriasis, leading to the identification of both known and novel disease mechanisms.
- The approach was further applied to necrobiosis lipoidica, revealing important disease drivers and potential treatments, demonstrating a high success rate in matching drugs to identified molecular targets.
Article Synopsis
- Corticostriatal connections play a key role in motivation and behavior, and rs-fMRI is being explored as a tool to investigate these connections in relation to neuropsychiatric disorders.
- The study used tract-tracing in non-human primates to confirm that rs-fMRI data reflects these connections in both primates and humans, mapping the striatal input from various prefrontal regions.
- They found significant overlap in striatal projection zones, particularly in the medial rostral dorsal caudate, providing a foundation for future research that could lead to targeted treatments for neurological and psychiatric conditions.
Article Synopsis
- Non-infectious cutaneous vasculitis often leads to skin biopsies being tested with direct immunofluorescence (DIF), but the clinical value of this testing hasn't been thoroughly assessed.
- This scoping review evaluated peer-reviewed literature from 1975 to 2023 on the utility of DIF in vasculitis to help develop guidelines for its appropriate use.
- The review found DIF has a sensitivity of around 75% and can aid in diagnosing and distinguishing subtypes of vasculitis, but further research is needed to compare DIF's effectiveness against routine microscopy.
We present the development of a new astrochemical research tool, HILTRAC, the Highly Instrumented Low Temperature ReAction Chamber. The instrument is based on a pulsed form of the CRESU (Cinétique de Réaction en Écoulement Supersonique Uniforme, meaning reaction kinetics in a uniform supersonic flow) apparatus, with the aim of collecting kinetics and spectroscopic information on gas phase chemical reactions important in interstellar space or planetary atmospheres. We discuss the apparatus design and its flexibility, the implementation of pulsed laser photolysis followed by laser induced fluorescence, and the first implementation of direct infrared frequency comb spectroscopy (DFCS) coupled to the uniform supersonic flow.
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- A pediatric patient with ichthyosis vulgaris and global anhidrosis was diagnosed with erythema ab igne (EAI) after developing brown patches on his skin due to chronic heat exposure.
- Extensive tests were done to exclude other possible causes, such as autoimmune or genetic conditions, but they yielded no clear results.
- The case highlights the importance of thorough history taking in diagnosing rare conditions like EAI in children.
Lichen planus (LP), an idiopathic, multifaceted chronic inflammatory disease with a heterogeneous clinical presentation, affects approximately 0.5-1% of the population. The various clinical manifestations of LP fall into three broad categories, namely cutaneous, appendageal, and mucosal, with further subclassification depending on the morphology and distribution patterns of individual lesions.
View Article and Find Full Text PDFBackground: Current strategies for hypertrophic scar prevention and treatment are limited.
Objective: To facilitate these efforts, a minimally invasive hypertrophic scar model was created in a rabbit ear for the first time based on previous methods used to induce ischemia.
Methods: Six New Zealand white rabbits (12 ears total) were studied.
Article Synopsis
- - Sweat gland neoplasms are complex and rare skin tumors, making them a tricky area for doctors who study skin diseases (dermatopathology) and recent research has revealed different biological markers for several types of these tumors.
- - A study evaluated various sweat gland tumors in patients, using techniques like immunohistochemistry and RNA sequencing to help identify specific tumor types based on their unique features.
- - Findings showed that specific tests, such as p63 IHC, BRAF V600E IHC, and MAML2 FISH, can effectively assist in accurately diagnosing sweat gland tumors, offering valuable tools for pathologists when the usual assessment is unclear.