Publications by authors named "Julia L Scheithauer"
Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3/8 activity.
Proc Natl Acad Sci U S A
April 2024
Article Synopsis
- Apolipoprotein AV (APOA5) helps lower fat levels (triglycerides) in the blood by stopping another protein complex (ANGPTL3/8) from interfering with lipoprotein lipase (LPL), which breaks down fats.
- Researchers found that a mutation in APOA5 leads to higher triglyceride levels, meaning certain parts of the protein are needed to perform its job well.
- Experiments with mice showed that the normal version of APOA5 worked to reduce triglyceride levels, while a modified version without important parts didn’t, highlighting those parts' key role in keeping fat levels in check.