Publications by authors named "Julia L Crunden"
Heat-shock protein 90 (Hsp90) is a central regulator of cellular proteostasis. It stabilizes numerous proteins that are involved in fundamental processes of life, including cell growth, cell-cycle progression and the environmental response. In addition to stabilizing proteins, Hsp90 governs gene expression and controls the release of cryptic genetic variation.
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- Age-related hearing loss often starts with a decline in sensitivity to high frequencies, but this study focuses on two mutant mouse lines with a unique low-frequency hearing impairment linked to the Klhl18 gene.
- Both mutant strains exhibited normal hearing at 3 weeks, but a progressive decline in auditory brain responses was noted starting at 4 weeks, while cochlear function remained unaffected.
- Microscopic analysis revealed that the inner hair cell stereocilia were abnormally tapered in the mutants, suggesting that the Klhl18 gene plays a crucial role in maintaining normal inner hair cell structure and function, particularly at low frequencies.
The highly conserved, ubiquitous molecular chaperone Hsp90 is a key regulator of cellular proteostasis and environmental stress responses. In human pathogenic fungi, which kill more than 1.6 million patients each year worldwide, Hsp90 governs cellular morphogenesis, drug resistance, and virulence.
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