Publications by authors named "Julia Kugler"
Article Synopsis
- Inflammatory bowel diseases (IBD) cause long-lasting inflammation in the digestive system, and scientists are looking into how stress inside cells (called ER stress) affects this.
- They found that when cells experience ER stress, the way they use certain nutrients changes, which might affect how severe IBD is and how well treatments work.
- The researchers discovered that not having enough of a nutrient called serine can mess up a signaling system that helps cells fight infections, but giving antioxidants can help improve this issue.
Anastomotic leakage (AL) accounts for a major part of in-house mortality in patients undergoing colorectal surgery. Local ischemia and abdominal sepsis are common risk factors contributing to AL and are characterized by upregulation of the hypoxia-inducible factor (HIF) pathway. The HIF pathway is critically regulated by HIF-prolyl hydroxylases (PHDs).
View Article and Find Full Text PDFThe HIF hydroxylase enzymes (PHD1-3 and FIH) are cellular oxygen-sensors which confer hypoxic-sensitivity upon the hypoxia-inducible factors HIF-1α and HIF-2α. Microenvironmental hypoxia has a strong influence on the epithelial and immune cell function through HIF-dependent gene expression and consequently impacts upon the course of disease progression in ulcerative colitis (UC), with HIF-1α being protective while HIF-2α promotes disease. However, little is known about how inflammation regulates hypoxia-responsive pathways in UC patients.
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