Publications by authors named "Julia Kokosza"
Eur Biophys J
October 2023
Article Synopsis
- Nudt15 is a well-studied enzyme from the NUDIX protein family, primarily for its effects on thiopurine drugs used in cancer and inflammatory disease treatment.
- Besides its known activity on thiopurines, Nudt15 also acts on various nucleotide substrates, and there's speculation about its role in the degradation of mRNA through hydrolysis of mGDP.
- Recent research showed that Nudt15 has moderate activity with methylated forms of GDP and GTP, suggesting these can inform the design of new small molecule inhibitors targeting Nudt15.
