Publications by authors named "Julia Klaussner"
Article Synopsis
- The study investigates Antibiotic-Refractory Lyme Arthritis (ARLA), focusing on the complex T cell responses that initially target the Lyme bacteria and potentially shift to attacking the body's own proteins, but the exact mechanisms remain unclear.
- Researchers utilized flow cytometry, T cell receptor sequencing, and single-cell RNA sequencing to analyze T helper cells from patients' inflamed joints in Europe, discovering a specific TCR-β motif linked to ARLA that was not common in North American patients.
- The findings reveal a distinct TCR response in ARLA patients that drives the growth of pathogenic T helper cells, providing insights into the immune system's maladaptive responses and aiding future identification of key antigens involved in
Objective: Antinuclear antibody (ANA)-positive juvenile idiopathic arthritis (JIA) is characterized by synovial B cell hyperactivity, but the precise role of CD4+ T cells in promoting local B cell activation is unknown. This study was undertaken to determine the phenotype and function of synovial CD4+ T cells that promote aberrant B cell activation in JIA.
Methods: Flow cytometry was performed to compare the phenotype and cytokine patterns of PD-1 CD4+ T cells in the synovial fluid (SF) of patients with JIA and T follicular helper cells in the tonsils of control individuals.