CCR2-dependent Gr1 monocytes promote kidney injury in shiga toxin-induced hemolytic uremic syndrome in mice.

The hemolytic uremic syndrome (HUS) is a life-threatening disease of the kidney that is induced by shiga toxin-producing E.coli. Major changes in the monocytic compartment and in CCR2-binding chemokines have been observed.

-dependent CD103CD11b dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus.

Objective: Postoperative ileus (POI), the most frequent complication after intestinal surgery, depends on dendritic cells (DCs) and macrophages. Here, we have investigated the mechanism that activates these cells and the contribution of the intestinal microbiota for POI induction.

Design: POI was induced by manipulating the intestine of mice, which selectively lack DCs, monocytes or macrophages.